Product

A reversible proteasome-inhibiting boroxine intermediate—sometimes filed as an alternative API—used as a stable, moisture-resistant precursor for GMP manufacture of bortezomib destined for multiple-myeloma and mantle-cell-lymphoma therapies.

  • Product type: Proteasome-inhibitor precursor / alternative API (cyclic boroxine intermediate)
  • Synonym:  PS-341, anhydrous bortezomib, boroxine
  • CAS: 390800-88-1 
  • Common applications: Stabilised GMP intermediate used for downstream mannitol complexation to manufacture the therapeutic bortezomib drug substance for multiple myeloma and mantle-cell lymphoma.