MMAF (Monomethyl Auristatin F) is a synthetic anti-tumor agent known for its antimitotic properties, derived as an auristatin derivative. This compound acts as an antitubulin agent, blocking cell division by inhibiting the polymerization of tubulin, a crucial protein for cell division​. MMAF has found its application as a cytotoxic payload in antibody-drug conjugates (ADCs) aimed at targeted cancer therapy.

Besides MMAF, TBD offers an array of MMAF derivatives and linkers suitable for diverse ADC-related applications. Refer to the examples section for a list of production-ready solutions.

For further details or inquiries regarding other solutions, feel free to contact us directly.

  • Product type: ADC payloads and linkers
  • Examples:
    • MMAF (745017-94-1)
    • Val-Cit-PAB-MMAF-Ome ( 863971-56-6)
    • MMAF ester free base (863971-12-4)
  • Common applications: precision cancer treatment