The “Small-Molecule Novel Drug Ingredients Lab” project aims to establish a state-of-the-art facility for developing and pilot-scale manufacturing of active pharmaceutical ingredients (APIs) for early-stage (Phase I) clinical trials. This new lab will include four units: a cGMP suite for handling APIs at pilot scale, synthetic chemistry areas for 100 g to kilogram-scale work, and an analytical chemistry unit.
| Equipment | Purpose | Services |
|---|---|---|
| 5 kg flash | Rapid purification of target compound mixtures in R&D or pilot processes | |
| 150L jacketed reactor | Temperature-controlled reactions at scale for small-molecule synthesis | |
| Preparative Flash Chromatography with an ELSD marks | Purification of non-UV-active compounds with evaporative light-scattering detection | |
| Membrane vacuum pumps | Used for solvent evaporation or filtration processes when using reactor systems. | |
| Vacuum pumps | Generate vacuum for ovens for drying products. | |
| Rotary evaporator | Used for efficient solvent removal under reduced pressure. Used together with 150L reactor setup for evaporations that need deep vacuum. | |
| Vacuum drying ovens | Ovens used in our 2 bigger pilot production rooms to dry APIs or intermediates under vacuum to remove residual solvents. | |
| Reactor systems 1000L, 630L | Pilot production reactor systems for line 1 to perform chemical reactions at larger scale. Used for synthesis and crystallization during API production steps. | |
| Reactor systems 400L, 250L, 160L | Pilot production reactor systems for line 2 to perform chemical reactions at larger scale. Used for synthesis and crystallization during API production steps. | |
| Glass tank with stirrer system | Used for extraction purposes to assist working with glass-lined reactors in pilot production line 1. | |
| Centrifuges | Used to separate solids from liquids after crystallization or filtration in new pilot production rooms. | |
| Nutsche filters | Used for solid-liquid separation under vacuum or pressure working with glass-lined equipment. Also used for hot filtration purposes. | |
| Nutsche filters (up to 150L) | Used for solid-liquid separation under vacuum or pressure. Will also be used for hot filtration purposes. Capacity up to 150L. | |
| Pressure filter | Used for solid-liquid separation under vacuum or pressure working with glass-lined equipment. Also used for hot filtration purposes. | |
| Glass-lined mixer | Used for mixing suspensions and pre-reaction blending. Supports pilot production line 1. | |
| Vacuum drying ovens (150L rooms) | Ovens used in 150L production line rooms to dry APIs or intermediates under vacuum and remove residual solvents. | |
| High-pressure reactor | Carries out reactions under high pressure and temperature. Used for hydrogenations. | |
| Reactor system up to 150L | Used to perform small-scale reactions and scale-up activities. | |
| Distillation system | Separates components based on boiling point differences. Used for deep vacuum distillation as a purification step. | |
| Glass tank with stirrer (Line 2) | Used for extraction purposes to assist working with glass-lined reactors in pilot production line 2. |
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