MMAE (Monomethyl Auristatin E) is a powerful synthetic antineoplastic agent, originated from dolastatin 10, a compound extracted from the sea hare Dolabella auricularia. Known for its pronounced cytotoxicity, MMAE serves as a payload in antibody-drug conjugates (ADCs) aimed at targeted cancer treatment.

Besides MMAE, TBD offers an array of MMAE derivatives and linkers suitable for diverse ADC-related applications. Refer to the examples section for a list of production-ready solutions.

For further details or inquiries regarding other solutions, feel free to contact us directly.

  • Product type: ADC payloads and linkers
  • Examples:
    • MMAE (474645-27-7)
    • Maleimide–(CH2)5-Asp-Ile-Pro-Val-Ser–PAB–MMAE
    • Maleimidocaproyl-Val-Cit-PAB-MMAE (646502-53-6)
  • Common applications: precision cancer treatment